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종양연구소 조회수:243
2017-05-18 09:55:49

국외 전문 학술지 

RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3.

Jang JW1, Kim MK1, Lee YS1, Lee JW1, Kim DM1, Song SH1, Lee JY1, Choi BY1, Min B1, Chi XZ1, Bae SC1.

                              (2016) 2016 Jul 18. doi: 10.1038/onc.2016.266.


RUNX family members are covalently modified and regulated by PIAS1-mediated sumoylation.

Kim JH1, Jang JW1, Lee YS1, Lee JW1, Chi XZ1, Li YH1, Kim MK1, Kim DM1, Choi BS1, Kim J1,                                       Kim HM2, van Wijnen A3, Park I4, Bae SC1.

                      (2014)  2014 Apr 28;3:e101. doi: 10.1038/oncsis.2014.15.



Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. 

Lee YS1, Lee JW, Jang JW, Chi XZ, Kim JH, Li YH, Kim MK, Kim DM, Choi BS, Kim EG, Chung JH, Lee OJ, Lee YM, Suh JW, Chuang LS, Ito Y, Bae SC.


(2013) 2013 Nov 11;24(5):603-16. doi: 10.1016/j.ccr.2013.10.003.


Identification of RUNX3 as a component of the MST/Hpo signaling pathway.

Min B, Kim MK, Zhang JW, Kim J, Chung KC, Oh BC, Stein GS, Lee YH, van Wijnen AJ, Bae SC.

(2011) JOURNAL OF Cellular Physiology [Abstract]

Nicotinamide inhibits growth of carcinogen induced mouse bladder tumor and human bladder tumor xenograft through up-regulation of RUNX3 and p300.

Kim WJ, Lee JW, Quan C, Youn HJ, Kim HM, Bae SC.

(2011) JOURNAL OF urology [Abstract]

Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.

Cinghu S, Goh YM, Oh BC, Lee YS, Lee OJ, Devaraj H, Bae SC.


Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growth.

Park SY, Lee KB, Lee MJ, Bae SC, Jang JJ.


Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice.

Lee JM, Shin JO, Cho KW, Hosoya A, Cho SW, Lee YS, Ryoo HM, Bae SC, Jung HS.

(2011) DIFFERENTIATION [Abstract] 

Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs

Kim HJ, Bae SC.

(2011) Am J Transl Res [Abstract] 

 Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer .

Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC.

(2010) Oncogene [Abstract]

Src Kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC.

(2010) J Biol Chem [Abstract]

Runx3 expression in gastrointestinal tract epithelium:resolving the controversy

Ito k, Inoue KI, Bae SC, Ito

(2009) Oncogene [Abstract]


Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3

Kim JH, Choi JK, Cinghu S, Jang JW, Lee YS, Li YH, Goh YM, Chi XZ, Lee KS, Wee H, Bae SC.

(2009) J Cell Biochem [Abstract]


 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi XZ, Kim J, Lee YH, Lee JW, Lee KS, Wee H, Kim WJ, Park WY, Oh BC, Stein GS, Ito Y, van Wijnen AJ, Bae SC.

(2009) Cancer Res [Abstract]


PEBP2{beta}/CBF{beta}-dependent phosphorylation of RUNX1 and p300 by HIPK2: Implications for leukemogenesis.

Wee HJ, Voon DC, Bae SC, Ito Y.

(2008) Blood [Abstract]


Methylation of the RUNX3 Promoter as a Potential Prognostic Marker for Bladder

Eun-Jung Kim, Yong-June Kim, Pildu Jeong, Yun-Sok Ha, Suk-Chul Bae and Wun-jae Kim

(2008) The Journal of Urology 180:1141-1145 [Abstract]


E1A Physically Interacts With Runx3 and Inhibits Its Transactivation Activity

Eun-Jeong Cha, Byung-Chul Oh, Hee-Jun Wee, Xin-Zi Chi, Yun-Mi Goh, Kyeong-sook lee, Yoshiaki Ito, and Suk-Chul Bae

(2008) Journal of Cellular Biochemistry 105:236-244 [Abstract]


Molecular biomarkers in urothelial bladder cancer

Kim WJ, Bae SC

(2008) Cancer SCi 99(4):646-52 [Abstract]


Pim-1 kinase phosphorylates and stabilizes Runx3 and alters its subcellular

kim HR, Oh BC, Choi JK, Bae

(2008) J Cell Biochem. 9999:1-11[Abstract]


The Transcriptionj Factor runx3 Represses the Neurotrophin Receptor Trkb during Lineage Commitment of Dorsal Root Ganglion

Ken-ichi Inoue, Kosei Ito, Motomi Osato, Bernett Lee, Suk-Chul Bae, and Yoshiaki Ito

(2007) THE JOURNAL OF BIOLOGICAL CHEMISTRY. 282(33):24175-84  [Abstract]


Ca(2+)-inositol phosphate chelation mediates the substrate specificity of beta-propeller phytase.

Oh BC, Kim MH, Yun BS, Choi WC, Park SC, Bae SC, Oh TK.

(2006) Biochemistry. 45(31):9531-9.  [Abstract]


The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis.

Yano T, Ito K, Fukamachi H, Chi XZ, Wee HJ, Inoue K, Ida H, Bouillet P,Strasser A,Bae SC, Ito Y.

(2006) Mol Cell Biol. 26(12):4474-88. [Abstract]


Phosphorylation, acetylation and ubiquitination: the molecular

basis of RUNX regulation.

Bae SC, Lee YH

(2006) Gene. 366(1):58-66. Epub 2005 Dec 1. Review.[Abstract]


RNT-1, the C.elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development

Yon-ju Ji, Seunghee Nam, Yun-Hye Jin, Eun-Jung Cha, Kyeong-Sook Lee, Kyu-Yeong Choi, Hyun-Ok Song, Junho Lee, Suk-Chul Bae, Joohong Ahnn

(2004) Developmental Biology. vol 274 : 402-412 [Abstract]


Transforming Growth Factor-beta Stimulates p300-dependent RUNX3 Acetylation, Which Inhibits Ubiquitination-mediated Degradation

Yun-Hye Jin, Eun-Joo Jeon, Qing-Lin Li, Yong Hee Lee, Joong-Kook Choi, Wun-Jae Kim, Kwang-Youl Lee, and Suk-Chul Bae

(2004) Jnl Biological Chemistry. Vol. 279(28):29409-29417 [Abstract]


The RUNX Gene Family.

Yoshiaki Ito, Suk-Chul Bae.

(2004) Oncogene. Review Issue 4. Vol.23(24)

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

Li QL, Kim HR, Kim WJ, Choi JK, Lee YH, Kim HM, Shan Li L, Kim H, Chang J, Ito Y, Lee KY, Bae SC.

(2004 ) Biochem Biophys Res Commun. 314(1): 223-8.[Abstract]



Tumor Suppressor activity of Runx3.

Suk-Chul Bae and Joong-Kook Choi.

(2003) Oncogene. [Abstract]



Comment on Levanon et al., "Runx3 knockouts and stomach cancer", in EMBO reports (June 2003).

Bae SC, Ito Y

(2003) EMBO Rep. 4(6):538-9[Abstract]



Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development.

Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR.

(2002) Cell 111(5):621-33 [Abstract]

The protein kinase C pathway plays a central role in the FGF-stimulated expression and transactivation activity of Runx2.

Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ, Ryoo HM.

(2002) J Biol Chem [Abstract]


 Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein.

Lee KS, Hong SH, Bae SC.

(2002 Oct) Oncogene 17;21(47):7156-63 [Abstract]


 Runx3 controls the axonal projection of proprioceptive dorsal root  ganglion neurons
Ken-ichi Inoue, Shigeru Ozaki, Takashi Shiga, Kosei Ito, Tomoyuki Masuda, Nobuo Okado, Tsutomu Iseda, Saburo Kawaguchi, Masaharu Ogawa, Suk-Chul Bae, Namiko Yamashita, Shigeyoshi Itohara, Norio Kudo2 & Yoshiaki Ito

(2002 Oct) Nature Neuroscience Volume 5 Number 10 pp 946 - 954 [Abstract] 


  Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

Qing-Lin Li, Kosei Ito, Chohei Sakakura, Hiroshi Fukamachi, Ken-ichi Inoue, Xin-Zi Chi, Kwang-Youl Lee, Shintaro Nomura, Chang-Woo Lee, Sang-Bae Han, Hwan-Mook Kim,

Wun-Jae Kim, Hiromitsu Yamamoto, Namiko Yamashita, Takashi Yano, Toshio Ikeda, Shigeyoshi Itohara, Johji Inazawa, Tatsuo Abe, Akeo Hagiwara, Hisakazu Yamagishi, Asako Ooe, Atsushi Kaneda, Takashi Sugimura, Toshikazu Ushijima, Suk-Chul Bae, and Yoshiaki Ito

(2002) Cell, Vol 109, 113-124  [Abstract]


 Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans.

Seung-Hee Nam, Yun-Hye Jin, Qing-Lin Li, Kwang-Youl Lee, Goo-Bo Jeong, Yoshiaki Ito, Junho Lee, Suk-Chul Bae

(2002) Mol. Cell. Biol. Vol. 22, 457-554.  [Abstract]


 Cloning and expression pattern of a novel PEBP2b-binding protein (Charged amino acid rich leucine zipper [Crl-1]) in the mouse.

Takahiko Sakuma, Qing-Lin Lib, Youngho Jin, Lak-Wan Choi, Eung-Gook Kim, Kosei Ito, Yoshiaki Ito, Shintaro Nomura, Suk-Chul Bae

(2001), Mechanisms of Development, Vol. 104, 151-154[Abstract]


Intimate relation ship between TGF-b/BMP signaling and Runt domain transcription factor, PEBP2/CBF

Suk-Chul Bae, Kyung-Sook Lee, Yu-Wen Zhang and Yoshiaki Ito

(2001), J. Bone and Joint Surgery, Vol. 83-A, 48-55.  [Abstract]


Runx2/PEBP2aA/Cbfa1 is a common target of TGF-b1 and BMP-2 and cooperation between Runx2 and Smad5 induces osteoblast specific gene expression in the pluripotent mesenchymal precursor cell line C2C12

Kyeong-Sook Lee, Hyun-Jung Kim, Qing-Lin Li, Xin-Zi Chi, Chisato Ueta, Toshihisa Komori, John M Wozney, Eung-Gook Kim, Je-Young Choi, Hyun-Mo Ryoo and Suk-Chul Bae

(2000), Mol. Cell. Biol., Vol. 20 No. 23, pp 8783-8792  [Abstract]


cDNA cloning of run, a C. elegans Runt domain encoding gene.

Suk-Chul Bae, Junho Lee

(2000), Gene, Vol. 241, pp 255-258[Abstract]


Molecular detection of TEL-AML1 transcripts as a diagnostic tools and for monitoring of minimal residual disease in B-lineage childhood acute lymphoblastic leukemia.

Hyeon Jin Park, Kyeong Eun Lee, Jung Min Um, Soo Young Choe, Xin Zi Chi, Jun Ah Lee, Hee Young Shin, Hyo Seop Ahn, and Suk-Chul Bae

(2000), Mol. Cells, Vol. 10, pp 90-95.  [Abstract]


Regulation mechanism for the heterodimeric transcription factor, PEBP2/CBF                 

Suk-Chul Bae and Yoshiaki Ito

(1999), Histology and Histopathology, Vol. 14 pp 1213-1221  [Abstract]


Regulation of c-fos gene transcription and myeloid cell differentiation by AML1 and AML1-MGT8, a chimeric leukemogenic derivative of AML1.

Eun-Sook Hwang, Jeong-Ho Hong, Suk-Chul Bae, Yoshiki Ito and Seung-Ki Lee

(1999), FEBS letters, Vol. 446 pp. 86-90  [Abstract]


Expression of SET is modulated as a function of cell proliferation.

Kyeong-Sun Shin, Eun-Young Shin, Suk-Chul Bae, Seung-Ryul Kim, Goo-Bo Jeong, Sahng-June Kwak, Barbara J. Ballermann, and Eung-Gook Kim

(1999), J. Cell. Biochem. Vol. 74, pp 119-126.  [Abstract]


The PEBP2beta MYH11 fusion created  by inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.

Scott C Kogan, Eric Lagasse, Susan Atwater, Suk-Chul Bae, Irving Weissman Yoshiaki Ito, and J Michael Bishop

(1998), Proc. Natl.  Acad. Sci. USA.Vol. 95. pp 11863-11868.  [Abstract]


Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/Core  binding factor (CBFa) subunit by leukemia-related PEBP2/CBFb- SMMHC fusion protein inhibits  PEBP2/CBF-mediated transactivation.

Yuka Kanno, Mazuda Kano, Suk-Chul Bae, Kosei Ito, Yoshiaki Ito                                      

(1998), Mol. Cell. Biol.Vol. 18 pp 4252-4261.  [Abstract]


Negative regulation of granulocytic differentia tion of myeloid precusor cell line 32Dcl3 by ear-2, the mammalian homolog of Drosophila seven-up, and leukemogenic chimeric gene, AML1/ETO(MTG8).

Mee-Young Ahn, Gang Huang, Suk-Chul Bae, Hee-Jun Wee, Woo-Young Kim and Yoshiaki Ito

(1998),  Proc. Nacl. Acad. Sci. USA. Vol.95 pp. 1812-1817.  [Abstract]


A cDNA  cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia.

Yu-Wen Zhang, Suk-Chul Bae, Ei-ichi Takahashi,  and Yoshiaki Ito

(1997), Oncogene, Vol. 15. pp. 367-371.   [Abstract]


Myelomonoblastic leukaemia cells carrying the PEBP2β/MYH11 fusion gene are CD34, c-Kit+ immature cells.

Osato M., Asou N., Okubo T., Nishimura S., Yamasaki H., Era T., Suzushima H., Kawano F., Matsuoka R., Oka H., Bae S-C., Ito Y., Takatsuki K.

(1997), Br. J. Haematol. Vol. 97, pp 656-658.  [Abstract]


A novel transcript encoding an N-terminally truncated AML1/PEBP2αB protein interferes  differentiation of 32Dcl3 myeloid cells.

Yu-Wen Zhang, Suk-Chul Bae, Gang Huang, Yang-Xin Fu, Jie Lu, Mee-Young Ahn, Yuka Kanno, Tomohiko Kanno, and Yoshiaki Ito    

(1997),  Mol. Cell. Biol  Vol. 17, No. 7  pp. 4133-4145  [Abstract]


A retrovirus carrying the promyelocyte- retinoic acid receptor PML-RARα fusion  gene transforms haematophoietic progenitors in vitro and induces acute leukemias.

Muriel Altabef, Madeleine Garcia, Catherine Lavau, Suk-Chul Bae, Anne Dejean, Jacques Samarut.

(1996), EMBO J.  Vol. 15,  pp 2707-2716   [Abstract]


Comparison of the Genomic structure of the  runt domain encoding gene family.

Mee-Young Ahn, Suk-Chul Bae, Mitsuo Maruyama and Yoshiaki Ito.

(1996),  GENE,  Vol. 168, pp 279-280[Abstract]


Cloning, mapping and expression of PEBP2αC a third gene encoding the runt domain.  

Suk-Chul Bae, Ei-ichi Takahashi, Yu Wen Zhang Eiko-Ogawa, Katsuya Shigesada, Yuziro Namba, Masanobu Satake, Yoshiaki Ito   

(1995),  GENE   Vol. 159, pp 245-248.  [Abstract]              


Positive and Negative regulation of GM-CSF promoter activity by AML1 related transcription factor PEBP2.    

Atsushi Tarahashi, Masanobu Satake, Yuko Yamaguchi-Iwai, Suk-Chul Bae, Jie Lu, Mitsuo Maruyama, Yu-Wen Zhang, Hiroya Oka, Naoko Arai, Ken-ichi Arai, and Yoshiaki Ito

(1995), Blood, Vol. 86, No.2 p. 607-616.  [Abstract]


Subcellular localization of the α and β subunits of the acute myeloid leukemia   linked transription factor PEBP2/CBF.  

Jie Lu, Mitsuo Maruyama, Masanobu Satake,  Suk-Chul Bae, Eiko Ogawa, Hiroshi Kagoshima, Katsuya Shigesada, and Yoshiaki Ito

(1995), Mol. Cell. Biol. Vol. 15,  pp. 1651-1661.  [Abstract]


Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukimia cells by the DNA binding domain of PEBP2 and the AML1/MTG8 specific antisense oligonucleotide.

Chouhei Sakakura, Yuko Yamaguchi-Iwai, Masanobu Satake, Suk-Chul Bae, Atsushi Takahashi, Eiko Ogawa, Akeo Hagiwara, Toshio Takahashi, Akira Murakami, Kesuke Makino, Toshitaro Nakagawa,  Nanao Kamada, and Yoshiaki Ito

(1994),  Proc. Natl, Acad. Sci. U.S.A.   Vol. 91, pp. 11723-11727[Abstract]


PEBP2αB/mouse AML1 consists of multiple isoforms that posessess differential transactivation potentials.                

Suk-Chul Bae, Eiko Ogawa, Mitsuo Maruyama, Hiroya Oka, Masanobu Satake, Katsuya Shigesada, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland and Yoshiaki Ito

(1994), Mol. Cell. Biol. Vol. 14,  pp. 3242-3252.  [Abstract]


Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene AML1.     

Suk-Chul Bae, Yuko Yamaguchi-Iwai,  Eiko Ogawa, Mitsuo Maruyama, Manabu Inuzuka, Hiroshi Kagoshima,  Masanobu Satake, and Yoshiaki Ito.

(1993) Oncogene  Vol. 8,  pp. 809-814.   [Abstract]



국내 전문 학술지 


PEBP2/CBF의 활성 조절 기전 (review)
 1999년 The Korean Society of Endocrinology. Vol. 14. No. 2, pp 227-236
 배 석철


Osteoblast 분화에 미치는 BMP-2의 역할 (review)
 1998년 Korean Journal of Bone Metabolism Vol. 5, No 2, pp 83-95
 류 현모, 배석철


SNS 공유


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