충북대학교 종양연구소에서 다음과 같이 초청세미나를 개최하오니 많은 참여 부탁드립니다.
- 다 음 -
1. 연 자 : 오 병 철 교수 (가천대학교)
2. 일 시 : 2014년 7월 29일 (화) 오후 4시 30분
3. 연 제 : Tumor-specific MR Imaging Through Selective Uptake of Iron-Calcium-phytate
complex by Activated Macrophages.
4. 장 소 : 종양연구소 세미나실 104호
5. 발 표 내 용
Tumor-Specific MR Imaging Through Selective Uptake of Iron-Calcium-Phytate Complex by Activated Macrophages
Byung-Chul Oh, Lee Gil Ya Cancer and Diabetes Institute, Gachon University
Tumor-associated macrophages (TAMs) accumulate in various cancers and promote tumor angiogenesis and progression, but current methods have limited capability to visualize TAMs. Therefore, we reasoned that TAMs may be suitable imaging targets for non-invasive detection of tumors with high specificity. Here, we developed an Iron-Calcium-Phytate Complex (ICPC) for use as a magnetic resonance imaging (MRI) contrast agent that targets TAMs, and validated its efficacy for tumor-specific imaging in an orthotopic murine model of metastatic melanoma. Post-contrast MRI successfully detected micrometastatic melanoma with strict tumor-specificity. Histopathological findings suggested that tumor-specific MRI contrast images resulted from selective uptake of ICPC by TIE2+/CD31+ TAMs residing within tumor regions. Immunohistochemical analysis suggested that TIE2+/CD31+ macrophages are predominant macrophage populations infiltrating metastatic lymph nodes (MLNs). Importantly, TIE2+/CD31+ macrophages heavily infiltrated MLNs from human breast cancer biopsies, but not reactive hyperplastic lymph nodes. Thus, TIE2+/CD31+ macrophages can be used as novel histopathological biomarkers for metastasis in clinical diagnosis and may be a novel and promising target for tumour-specific imaging and cancer therapy.