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종양연구소 초청세미나 (2019.10.24)
종양연구소 조회수:29
2019-10-08 17:46:42

충북대학교 종양연구소에서 다음과 같이 초청세미나를 개최하오니 많은 참여 부탁드립니다.

 

                                  -    다    음   -

 

1. 연 자  :  박 현 우 교수 (연세대학교)

 

2. 일 시  :  2019년 10월 24일 (목)  오후 4시

 

3. 연 제  :  Regulation of Hippo-YAP/TAZ Pathway in Cancer Biology

 

4. 장 소  :  종양연구소 세미나실 104호 

 

5. 발 표 내 용 

Regulation of Hippo-YAP/TAZ Pathway in Cancer Biology

 

The Hippo-YAP/TAZ Signaling Pathway have emerged as key regulator of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here I will present an overview of various upstream regulators of Hippo-YAP/TAZ and TEAD including Mechanotransduction, GPCR ligands, Cell Polarity, and Energy stress as potential targets for anticancer therapies. I will also focus on our recent findings on YAP/TAZ as bona fide effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation via the alternative Wnt pathway that is independent of Wnt/b-catenin signaling. In addition, we recently identified TAZ expression in leukemia and macrophage cells in several pathologic contexts, which suggest a novel function of Hippo signaling in leukemogenesis and immunity. Unlike YAP/TAZ, the transcription factor TEAD are constantly nuclear. However, our recent findings revealed that specific stress promotes cytoplasmic translocation of TEAD via protein-protein interaction with p38 MAPK. Importantly, inhibition of TEAD by p38-induced cytoplasmic translocation suppresses YAP/TAZ-driven cancer cell growth. Therefore, the Hippo pathway is an attractive target for anticancer drug development.

 
 
 
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