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MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage r
종양연구소 조회수:224
2020-03-16 10:56:37

 

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response.

 

 2020 Feb 21;11(1):1009. doi: 10.1038/s41467-020-14614-4.

 

The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, the biological importance of this gene in NE-type lung cancer in vivo remains unclear. Here, we established an ATII-specific KrasG12D/+/Men1-/- driven genetically engineered mouse model and show that deficiency of menin results in the accumulation of DNA damage and antagonizes oncogenic Kras-induced senescence and the epithelial-to-mesenchymal transition during lung tumorigenesis. The loss of menin expression in certain human primary lung cancers correlates with elevated NE profiles and reduced overall survival.

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