충북대학교 종양연구소에서 다음과 같이 초청세미나를 개최하오니 많은 참여 부탁드립니다.
- 다 음 -
1. 연 자 : 박 현 우 교수 (연세대학교)
2. 일 시 : 2019년 10월 24일 (목) 오후 4시
3. 연 제 : Regulation of Hippo-YAP/TAZ Pathway in Cancer Biology
4. 장 소 : 종양연구소 세미나실 104호
5. 발 표 내 용
Regulation of Hippo-YAP/TAZ Pathway in Cancer Biology
The Hippo-YAP/TAZ Signaling Pathway have emerged as key regulator of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here I will present an overview of various upstream regulators of Hippo-YAP/TAZ and TEAD including Mechanotransduction, GPCR ligands, Cell Polarity, and Energy stress as potential targets for anticancer therapies. I will also focus on our recent findings on YAP/TAZ as bona fide effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation via the alternative Wnt pathway that is independent of Wnt/b-catenin signaling. In addition, we recently identified TAZ expression in leukemia and macrophage cells in several pathologic contexts, which suggest a novel function of Hippo signaling in leukemogenesis and immunity. Unlike YAP/TAZ, the transcription factor TEAD are constantly nuclear. However, our recent findings revealed that specific stress promotes cytoplasmic translocation of TEAD via protein-protein interaction with p38 MAPK. Importantly, inhibition of TEAD by p38-induced cytoplasmic translocation suppresses YAP/TAZ-driven cancer cell growth. Therefore, the Hippo pathway is an attractive target for anticancer drug development.